Material Safety Data Sheet – 1,3-Dibromobenzene

Identification

Product Name: 1,3-Dibromobenzene
CAS Number: 108-36-1
EC Number: 203-576-7
Chemical Formula: C6H4Br2
Synonyms: m-Dibromobenzene, meta-Dibromobenzene
Recommended Use: Laboratory chemicals, industrial manufacturing processes, chemical synthesis
Supplier: Contact details of the supplier or manufacturer must be provided with address, phone, and emergency contact.

Hazard Identification

Classification: Acute toxicity (oral), Skin irritation, Eye irritation, Hazardous to the aquatic environment
Signal Word: Warning
Hazard Statements: Harmful if swallowed, can cause skin and eye irritation, toxic to aquatic life with long-lasting effects
Pictograms: Exclamation mark, environment symbol
Precautionary Statements: Avoid breathing dust or fumes, avoid contact with skin and eyes, wash hands thoroughly after handling, use only outdoors or in a well-ventilated area, avoid release to the environment
Physical Hazards: Slightly flammable, can release toxic fumes if heated
Health Hazards: Can cause nausea, vomiting, and irritation if ingested, inhaled, or comes into contact with skin and eyes
Environmental Hazards: Persistent in the environment, toxic to aquatic organisms

Composition / Information on Ingredients

Chemical: 1,3-Dibromobenzene
Concentration: ≥ 99% (pure substance)
Impurities: Typically less than 1% total impurities, identity specified in supplier CoA
Molecular Weight: 235.91 g/mol

First Aid Measures

General Advice: Remove contaminated clothing, seek medical attention if symptoms persist
Inhalation: Move person to fresh air, keep at rest, if not breathing provide artificial respiration, seek medical care
Skin Contact: Wash with soap and lots of water for several minutes, remove contaminated clothing, get medical help for irritation or persistent symptoms
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, continue rinsing, seek attention
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice promptly
Symptoms: May include headache, drowsiness, irritation of skin, respiratory tract, and digestive tract

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Hazards from Combustion: Decomposition products may include hydrogen bromide, bromine gas, harmful organic compounds
Fire-Fighting Advice: Firefighters should wear full protective gear and self-contained breathing apparatus, contain contaminated water runoff
Specific Hazards: Can emit toxic and corrosive fumes under fire conditions

Accidental Release Measures

Personal Precautions: Evacuate area, ventilate space, wear appropriate protective equipment including gloves and safety goggles
Environmental Precautions: Prevent spillage from entering drains, surface water, or soils
Methods for Clean-Up: Soak up with inert material (sand, earth), place in chemical waste container, clean spill area thoroughly with detergent and water
Disposal: Dispose in accordance with local regulations, do not allow material to contaminate waterways

Handling and Storage

Handling: Handle in fume hood or ventilated area, avoid contact with skin and eyes, avoid inhaling vapor or dust, wash hands before breaks or after handling
Storage Conditions: Store in tightly closed containers, keep in cool, well-ventilated area away from sources of ignition or incompatible substances
Incompatible Materials: Strong oxidizers, strong alkalis, strong acids
Hygiene Measures: Do not eat, drink, or smoke near product, use appropriate cleaning methods for contaminated surfaces

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limits established; handle as hazardous chemical
Engineering Controls: Use only in well-ventilated areas, preferably in chemical fume hood
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety glasses or goggles, protective clothing, appropriate respirator if ventilation is insufficient
Environmental Exposure Control: Avoid release to environment, use containment to reduce spill risks

Physical and Chemical Properties

Appearance: White to off-white crystalline solid
Odor: Faint, aromatic odor
Odor Threshold: Not readily determined
pH: Not applicable (insoluble in water)
Melting Point: 86°C – 88°C
Boiling Point: 220°C – 222°C
Flash Point: 96°C (closed cup)
Evaporation Rate: Not available
Flammability: Combustible at elevated temperatures
Vapor Pressure: 0.05 mmHg at 25°C
Solubility: Poorly soluble in water (<1 mg/L), soluble in many organic solvents
Partition Coefficient (log Kow): About 3.8
Vapor Density: >1 (air = 1)
Relative Density: 2.1 (water = 1)
Decomposition Temperature: Not precisely established, decomposes forming toxic fumes

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: High temperature, open flame, static electricity, incompatible materials
Incompatible Materials: Strong oxidizers, alkalis and acids, moisture
Hazardous Decomposition Products: Hydrogen bromide, bromine, carbon oxides
Polymerization: Does not undergo hazardous polymerization

Toxicological Information

Acute Toxicity: Harmful if swallowed (oral LD50 in rats estimated 1400 mg/kg)
Skin Irritation: May cause mild skin irritation on contact
Eye Damage/Irritation: Causes irritation, possible redness or tearing
Inhalation: Breathing dust or fumes can cause headache, irritation to respiratory tract
Chronic Toxicity: Limited data, no clear evidence of carcinogenicity or reproductive harm
Sensitization: Not a known sensitizer
Mutagenicity: No data suggesting mutagenicity in standard tests
Routes of Exposure: Swallowing, inhalation, skin, and eye contact

Ecological Information

Eco-Toxicity: Toxic to aquatic organisms (LC50 for fish: 2 – 10 mg/L, 96 hr)
Persistence and Degradability: Persistent, slow degradation in the environment
Bioaccumulative Potential: Can accumulate in aquatic species, bio-concentration factor calculated as high
Mobility in Soil: Low mobility due to hydrophobic nature, tends to adsorb to soil and sediments
Other Adverse Effects: Substantial risk for aquatic life with long-term exposure

Disposal Considerations

Disposal Methods: Chemical waste should go through incineration under controlled conditions, or according to local regulations
Contaminated Packaging: Dispose as hazardous waste, thoroughly clean containers prior to disposal
Disposal Precautions: Avoid direct release to the environment, consult local environmental authority for further guidance

Transport Information

UN Number: 1993
UN Proper Shipping Name: Flammable liquids, n.o.s. (includes 1,3-Dibromobenzene)
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III
Hazard Labels: Flammable liquid, Environmental hazard symbol applies
Environmental Hazards: Yes, marine pollutant
Special Precautions: Keep away from incompatible cargo, avoid temperature extremes, safeguard from leakage

Regulatory Information

US TSCA Inventory: Listed
EU REACH Registration: Existing chemical, registration number supplied by manufacturer
OSHA: Hazardous chemical, workplace controls apply
SARA Title III: No specific reporting thresholds, but considered hazardous
WHMIS (Canada): D2B (Toxic material causing other effects), B3 (Combustible liquid)
Japan ENCS, Australia AICS, China IECSC: Listed
Restrictions: Observe country-specific rules regarding safe use, storage, and disposal