Material Safety Data Sheet: 2-Bromobutane

Identification

Product Name: 2-Bromobutane
Chemical Formula: C4H9Br
CAS Number: 78-76-2
Recommended Use: Chemical intermediate, laboratory reagent
Supplier: Provided by chemical distributor or manufacturer
Emergency Contact: Refer to local emergency number listed on shipping documents

Hazard Identification

GHS Classification: Flammable liquids, Category 3; Acute toxicity (oral), Category 4; Skin irritation, Category 2; Eye irritation, Category 2A; Specific target organ toxicity – single exposure, Category 3
Label Elements: Flame symbol, exclamation mark
Signal Word: Warning
Hazard Statements: Flammable liquid and vapour. Harmful if swallowed. Causes skin and eye irritation. May cause respiratory irritation.
Precautionary Statements: Keep away from heat, sparks, open flames. Avoid breathing vapours. Wash skin thoroughly after handling. Wear protective gloves, clothing, and eye protection.

Composition / Information on Ingredients

Chemical Name: 2-Bromobutane
Synonyms: sec-Butyl bromide, 2-bromobutan
Content: >99% by weight
Impurities: Trace hydrocarbons, possible residual solvents

First Aid Measures

Inhalation: Move person to fresh air. Get medical attention if respiratory symptoms occur or persist.
Skin Contact: Remove contaminated clothing. Wash with mild soap and plenty of water. Seek medical advice for irritation or burns.
Eye Contact: Rinse cautiously with plenty of water for 15 minutes. Remove contact lenses if present and easy to do. Call a physician if irritation persists.
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical attention immediately.
Most Important Symptoms: Irritation of respiratory tract, eyes, and skin; headache, nausea.

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, alcohol-resistant foam, or carbon dioxide; water spray for larger fires.
Unsuitable Extinguishing Media: Direct water jet.
Special Hazards: Vapours can form explosive mixtures with air. Combustion yields toxic bromide and carbon oxides.
Protective Equipment: Firefighters wear full protective gear and self-contained breathing apparatus.
Advice: Cool containers exposed to fire with water spray. Remove contaminated material from fire area.

Accidental Release Measures

Precautions: Evacuate area, ensure adequate ventilation, eliminate ignition sources.
Spill Response: Contain and collect spillage using non-sparking tools and inert absorbent, such as sand or vermiculite. Place in suitable waste container.
Personal Protection: Wear gloves, goggles, respiratory protection as needed.
Environmental Precautions: Prevent entry into drains, ground water, or surface water.

Handling and Storage

Handling: Use in chemical fume hood. Avoid inhalation, skin or eye contact. No eating, drinking or smoking. Bond containers and use spark-proof equipment.
Storage Conditions: Keep in tightly sealed containers in a cool, well-ventilated place away from sources of heat and ignition. Segregate from oxidizers, acids, and incompatible chemicals.
Incompatibilities: Strong oxidizing agents, strong bases, strong acids.
Packaging Materials: Store only in containers compatible with organic solvents.

Exposure Controls and Personal Protection

Occupational Exposure Limits: Not established by OSHA, ACGIH, or EU. Minimize exposure.
Engineering Controls: Local exhaust ventilation, safety shower and eyewash station near work area.
Personal Protective Equipment: Chemical-resistant gloves, splash goggles, lab coat, respirator for vapours if exposure above threshold.
Hygiene Measures: Wash hands before breaks and after handling. Do not eat, drink, or smoke near working area.

Physical and Chemical Properties

Physical State: Liquid
Colour: Colourless to light yellow
Odour: Sweet, ether-like
Boiling Point: 91-93°C
Melting Point: -119°C
Flash Point: 17°C (closed cup)
Auto-ignition Temperature: 370°C
Flammability: Flammable
Vapour Pressure: 86 hPa at 20°C
Solubility: Slightly soluble in water; soluble in most organic solvents
Density: 1.26 g/cm³ at 20°C
Partition Coefficient (log Kow): Around 2

Stability and Reactivity

Chemical Stability: Stable at standard temperature and pressure, away from ignition sources.
Hazardous Reactions: Vapours may react violently with strong bases, alkali metals, or oxidizers. Generates toxic bromide fumes if burned.
Conditions to Avoid: Sparks, open flames, excess heat, incompatibles.
Decomposition Products: Combustion produces hazardous carbon oxides, hydrogen bromide.

Toxicological Information

Acute Toxicity: LD50 (oral, rat): about 1800 mg/kg. LD50 (dermal, rabbit): data not fully available.
Inhalation Effects: Vapours cause central nervous system effects: headache, dizziness, nausea, potential unconsciousness.
Skin Corrosion/Irritation: Causes irritation with potential for redness and blistering.
Eye Damage/Irritation: Causes eye irritation, redness, watering.
Chronic Effects: Prolonged or repeated exposure may harm liver, kidneys. Possible risk for mutagenicity not fully assessed.

Ecological Information

Aquatic Toxicity: Moderately toxic to aquatic organisms.
Persistence and Degradability: Not rapidly degradable; tends to persist in environment.
Bioaccumulative Potential: Moderate potential for bioaccumulation (based on log Kow).
Mobility in Soil: Low-to-moderate mobility depending on local soil types and rainfall.
Other Adverse Effects: Release to environment should be minimized.

Disposal Considerations

Waste Treatment Methods: Collect and deliver material and contaminated packaging to certified hazardous waste disposal facility.
Incineration: Chemical incineration under strict control with post-combustion and scrubber.
Precautions: Do not discharge to sewers or waterways.
Contaminated Packaging: Triple rinse and manage as hazardous waste.

Transport Information

UN Number: 2344
UN Shipping Name: 2-Bromobutane
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: II
Hazard Labels: Flammable Liquid label required
Marine Pollutant: Not classified as marine pollutant
Special Precautions: Keep containers upright, away from sources of strong heat, in well-ventilated or fume-hood equipped vehicles.

Regulatory Information

U.S. Regulations: Not listed under CERCLA, SARA Title III sections 302 or 313. May require reporting under sections 311/312 as flammable and hazardous.
EU Regulations: REACH substance, authorization, restrictions apply. Labeling according to EU Classification, Labelling and Packaging (CLP) rules.
Canada: Listed on DSL/NDSL inventories.
Other Country Standards: Compliance with regulations on import, production, and storage as required by country of use.