Material Safety Data Sheet: 4-Bromochlorobenzene

Identification

Product Name: 4-Bromochlorobenzene
Chemical Formula: C6H4BrCl
Synonyms: 1-Bromo-4-chlorobenzene, p-Bromochlorobenzene
CAS Number: 106-39-8
Product Use: Laboratory chemical, chemical synthesis intermediate
Manufacturer/Supplier: Contact details should be listed on the product label
Emergency Phone Number: Refer to your local Poison Control Center or Emergency Response Number provided on the supplier’s label

Hazard Identification

Hazard Classification: Not classified as hazardous under GHS criteria for most jurisdictions, but can cause skin, eye, and respiratory tract irritation
Signal Word: Warning
Hazard Statements: May cause moderate eye and skin irritation; dust or vapor may irritate respiratory passages; not acutely toxic but prolonged exposure may have chronic health effects
Pictograms: Exclamation mark (for irritant)
Precautionary Statements: Avoid breathing dust; wash hands thoroughly after handling; avoid direct contact with skin and eyes

Composition / Information on Ingredients

Chemical Name: 4-Bromochlorobenzene
Concentration: 98–100% (pure substance)
Impurities/Stabilizing Additives: Trace amounts of other halogenated benzenes possible; no stabilizing additives mentioned in standard samples

First Aid Measures

Inhalation: Move affected person to fresh air; keep comfortable for breathing; seek medical advice if symptoms persist
Skin Contact: Wash immediately with plenty of soap and water; remove contaminated clothing; seek medical attention if irritation continues
Eye Contact: Rinse cautiously with water for at least 15 minutes; lift eyelids to ensure thorough flushing; seek medical attention if discomfort remains
Ingestion: Rinse mouth with water, do not induce vomiting; get medical assistance right away if any discomfort or symptoms appear
Note to Physician: Treat symptomatically; no specific antidote known

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, foam, CO2 or water spray
Specific Hazards Arising from Substance: Releases toxic fumes of hydrogen chloride, bromine compounds and carbon oxides when burned
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective clothing
Advice for Firefighters: Move containers from fire area if it can be done safely; cool containers with water spray if exposed to heat; avoid inhalation of decomposition products

Accidental Release Measures

Personal Precautions: Wear chemical-resistant gloves, safety goggles, and lab coat; avoid dust formation and dispersal
Environmental Precautions: Prevent spill from entering drains, sewers, waterways
Methods for Containment and Cleanup: Sweep up carefully to avoid creating dust; collect in a suitable container for proper disposal; ventilate area well after cleanup
Other Information: Decontaminate spill area using soap and water after material is collected

Handling and Storage

Handling: Handle in a well-ventilated area; avoid contact with skin, eyes, and clothing; do not breathe dust or vapor
Hygiene Practices: Wash hands before eating, drinking, or smoking; remove contaminated clothing and wash before reuse
Storage Conditions: Store in a tightly closed container in a cool, dry, well-ventilated place; keep away from strong oxidizing agents, acids, and bases; keep container clearly labeled
Other Advice: Follow local regulations for chemical storage

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limits established for this compound
Engineering Controls: Use good general room ventilation or fume hoods where generating dust or vapors; keep exposure as low as possible
Personal Protective Equipment: Wear protective gloves (nitrile recommended), safety goggles, and laboratory coat; respiratory protection (dust mask or respirator) recommended if ventilation is restricted
Other Protective Measures: Emergency eyewash and safety shower in work area recommended

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Weak aromatic odor
Odor Threshold: Not established
pH: Not applicable (solid compound)
Melting Point: 53–56°C (127–133°F)
Boiling Point: 219–221°C (426–430°F)
Flash Point: >110°C (closed cup)
Evaporation Rate: Not available
Flammability: Not easily flammable; may burn at high temperature
Vapor Pressure: 0.16 mmHg at 25°C
Vapor Density: Not available
Solubility: Insoluble in water; soluble in organic solvents like ethanol, benzene, diethyl ether
Partition Coefficient (Log Kow): 4.18 (estimated)
Auto-Ignition Temperature: Not available
Decomposition Temperature: Not available
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under normal conditions of storage and use
Reactivity: Not reactive under ambient conditions
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: May release toxic fumes of hydrogen chloride, bromine, and carbon oxides on decomposition
Possibility of Hazardous Reactions: Does not polymerize

Toxicological Information

Routes of Exposure: Skin, eyes, inhalation, ingestion
Acute Toxicity: Data limited; low oral toxicity in animal studies (mouse oral LD50 > 4000 mg/kg); skin or eye exposure may cause irritation
Chronic Effects: No conclusive data on long-term effects; avoid repeated or prolonged contact
Potential Health Effects: May cause irritation to skin, eyes, respiratory passages; central nervous system effects at high or prolonged exposure levels are possible in animal studies
Symptoms of Overexposure: Skin or eye redness, coughing, throat irritation, headache

Ecological Information

Ecotoxicity: Expected to be moderately toxic to aquatic organisms; specifics for fish, daphnia, or algae not widely published but likely harmful in large amounts
Persistence and Degradability: Degrades slowly in the environment; not rapidly biodegradable
Bioaccumulative Potential: Log Kow suggests potential for bioaccumulation in aquatic species
Mobility in Soil: Low solubility indicates restricted mobility, but may persist due to low degradation rate
Other Adverse Effects: Avoid release to environment; hazardous to aquatic systems

Disposal Considerations

Waste Treatment Methods: Dispose of according to local, regional, or national regulations
Recommended Disposal: Collect solid waste in sealed, labeled containers; deliver to licensed hazardous waste disposal contractor
Contaminated Packaging: Clean containers with water and detergent before disposal or recycling; treat as hazardous waste if contamination suspected
Additional Information: Do not discharge to sewers, soil, or natural water bodies

Transport Information

UN Number: Not regulated for transport under most international guidelines
Proper Shipping Name: 4-Bromochlorobenzene
Transport Hazard Class: Non-hazardous under DOT, IATA, and IMDG rules for small quantities
Packing Group: Not applicable
Marine Pollutant: Yes, avoid bulk releases into water
Special Transport Precautions: Keep container tightly closed and secure during transport; avoid physical damage or temperature extremes

Regulatory Information

US Regulations: Not listed as a hazardous substance under CERCLA, SARA Title III or TSCA 12(b); specific state lists may vary
Workplace Regulations: General chemical safety training recommended; follow OSHA Laboratory Standard and Hazard Communication requirements
Europe: Not listed on Annex XIV or XVII of REACH for special controls; general workplace safety directives apply
Other National Requirements: Consult local or national chemical safety and environmental protection agencies for additional rules or reporting obligations
Inventory Listings: Listed on TSCA (United States), EINECS (Europe), DSL (Canada), and other national chemical inventories