MSDS for 4-Bromofluorobenzene

Identification

Product Name: 4-Bromofluorobenzene
Synonyms: p-Bromofluorobenzene, 1-Bromo-4-fluorobenzene
Chemical Formula: C6H4BrF
CAS Number: 460-00-4
Recommended Uses: Laboratory reagent, organic chemical synthesis
Supplier: Chemical distributor or laboratory supplier contact information should appear on the label for access during emergencies and routine use.
Emergency Phone Number: Available via supplier — use for spill, exposure, or fire emergencies involving the product.

Hazard Identification

GHS Classification: Flammable liquids (Category 3), Acute toxicity (Category 4, oral and inhalation), Skin irritation (Category 2), Eye irritation (Category 2A)
Signal Word: Warning
Hazard Statements: May cause skin and eye irritation, harmful if swallowed, flammable liquid and vapor, may cause respiratory irritation
Pictograms: Flame, Exclamation Mark
Precautionary Statements: Avoid breathing dust, fumes, gas, mist, vapors, or spray; keep away from heat, sparks, and open flames; wear protective gloves and eye protection; wash hands thoroughly after handling; store in a well-ventilated place; keep container tightly closed.

Composition / Information on Ingredients

Chemical Name: 4-Bromofluorobenzene
Concentration: More than 98%
CAS Number: 460-00-4
Impurities: Less than 2%, specific identity not typically stated; impurities may include related halogenated benzenes.

First Aid Measures

Inhalation: Move affected person to fresh air immediately, keep at rest in a comfortable position, seek medical attention if experiencing symptoms like headache, nausea, dizziness, or respiratory irritation.
Skin Contact: Wash exposed skin thoroughly with soap and water, remove contaminated clothing, seek medical advice if redness or irritation persists.
Eye Contact: Rinse eyes cautiously with plenty of water for several minutes, remove contact lenses if present, continue rinsing, seek medical attention if irritation or pain persists.
Ingestion: Rinse mouth, never induce vomiting unless instructed by medical personnel, seek immediate medical attention for symptoms such as abdominal pain, nausea, or drowsiness.
Note to Physicians: Treat symptomatically and provide supportive therapy as needed.

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide.
Unsuitable Extinguishing Media: Direct water jets may spread fire.
Special Protective Equipment: Firefighters should use self-contained breathing apparatus and chemical protective clothing.
Specific Hazards: Combustion may release toxic gases including hydrogen bromide, hydrogen fluoride, and carbon oxides.
Advice for Firefighters: Evacuate area, fight fire from safe distance, prevent runoff from entering drains or watercourses, keep containers cool with water spray.

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, ensure adequate ventilation, avoid breathing vapors or contact with liquid, use appropriate PPE including gloves, goggles, and an organic vapor respirator if ventilation is poor.
Environmental Precautions: Prevent further leakage or spillage if safe to do so, do not let product enter drains or water sources.
Methods for Clean Up: Absorb spill with inert material such as sand or vermiculite, collect in appropriate chemical waste container, wash spill area thoroughly with water and detergent, ventilate area.
Notification: Report releases to designated authorities as required by local regulations.

Handling and Storage

Handling: Use only in well-ventilated areas, avoid breathing vapors or contact with eyes, skin, and clothing, do not eat, drink, or smoke while handling, wash thoroughly after handling material.
Storage: Keep container tightly closed in a dry and well-ventilated place, store away from heat sources, sparks, and open flame, segregate from oxidizing agents, acids, alkalis, and incompatible materials.
Incompatible Materials: Strong oxidizers, strong acids, bases, and sources of ignition.
Storage Temperature: Recommended storage at room temperature or below, protected from direct sunlight.

Exposure Controls and Personal Protection

Engineering Controls: Use fume hood or local exhaust ventilation to keep vapor concentrations low, maintain eyewash stations and safety showers in work area.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene recommended), safety goggles or face shield, flame-resistant laboratory coat, use organic vapor respirator for high concentrations.
Occupational Exposure Limits: Not established specifically for 4-Bromofluorobenzene, general organic vapor limits should be applied, keep workplace concentrations as low as possible.
Hygiene Measures: Wash hands before breaks and after handling, remove contaminated clothing and wash before reuse.

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Mild aromatic odor
Molecular Weight: 175.00 g/mol
Boiling Point: 162–164°C
Melting Point: Not applicable
Flash Point: 53°C (closed cup)
Autoignition Temperature: Not readily available
Vapor Pressure: 2.6 mmHg at 25°C
Solubility: Insoluble in water, soluble in organic solvents (ethanol, ether, acetone)
Density: 1.61 g/cm³ at 25°C
Viscosity: Not determined
Partition Coefficient (n-octanol/water): Approximately 3.5 (calculable, may vary)
Explosive Properties: Not explosive under normal conditions.

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Possibility of Hazardous Reactions: Does not polymerize, can react with strong oxidizers or reducing agents
Conditions to Avoid: Heat, open flames, sparks, sources of ignition, prolonged exposure to air
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Hydrogen bromide, hydrogen fluoride, carbon monoxide, carbon dioxide.

Toxicological Information

Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Moderate, may cause central nervous system effects, dizziness, nausea, headache, drowsiness
Skin Corrosion/Irritation: May cause mild to moderate irritation
Eye Damage/Irritation: May cause moderate irritation and redness
Respiratory Sensitization: Not classified as a respiratory sensitizer
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: Not available
Reproductive Toxicity: Not available
Chronic Effects: Prolonged or repeated exposure can cause dermatitis, defatting of skin, respiratory sensitization not well documented.
LD50 (oral, rat): >2000 mg/kg (estimated, specific data not widely published)
LD50 (dermal, rabbit): >2000 mg/kg (estimated)

Ecological Information

Toxicity to Aquatic Organisms: Toxic to aquatic life with long lasting effects (based on halogenated benzene data)
Persistence and Degradability: Not readily biodegradable, can remain in soil and water for extended periods
Bioaccumulative Potential: Likely to bioaccumulate in aquatic organisms due to hydrophobicity and high log Kow
Mobility in Soil: Expected to have low mobility, but potential for leaching exists if spilled in large volumes
Other Adverse Effects: No ozone depletion potential, environmental release should be minimized to avoid contamination of water bodies.

Disposal Considerations

Waste Treatment Methods: Dispose through a licensed chemical waste contractor, do not pour into drains or release to the environment
Disposal of Contaminated Packaging: Rinse containers, treat rinsate as chemical waste, follow local, state, and federal regulations
Special Precautions: Wear appropriate PPE during disposal, label waste containers with contents and hazards.
Environmental Hazards: Prevent disposal in open environment to minimize impact on aquatic and terrestrial ecosystems.

Transport Information

UN Number: UN 1993
Proper Shipping Name: Flammable liquid, n.o.s. (contains 4-Bromofluorobenzene)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Marine Pollutant: Yes
Special Precautions: Avoid transport with incompatible chemicals, secure loads to prevent tipping or container breach
Transport Labels: Flammable Liquid, Environmental Hazard where required.
Additional Notes: Check national and international transport regulations before shipping large quantities.

Regulatory Information

US TSCA: Listed
EC Inventory: Listed
Australia AICS: Listed
Canada DSL/NDSL: Listed
Hazard Symbols: Flammable, Harmful
Risk Phrases: R10 (Flammable), R20/21/22 (Harmful by inhalation, skin contact, and ingestion), R36/37/38 (Irritating to eyes, respiratory system, and skin)
Safety Phrases: S16 (Keep away from sources of ignition), S36/37/39 (Wear suitable protective clothing, gloves, eye/face protection), S61 (Avoid release to the environment)
Other Regulations: Not regulated as a controlled substance, not subject to special handling unless local requirements mandate additional precautions.